ART4
Ecto-ADP-ribosyltransferase 4 is an enzyme that in humans is encoded by the ART4 gene.[1][2] ART4 has also been designated as CD297 (cluster of differentiation 297).
This gene encodes a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. Antigens of the Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinositol-anchored to the erythrocyte membrane. Allelic variants, some of which lead to adverse transfusion reactions, are known.[2]
| Mouse Mutant Alleles for Art4 |
| Marker Symbol for Mouse Gene. This symbol is assigned to the genomic locus by the MGI |
Art4 |
| Mutant Mouse Embryonic Stem Cell Clones. These are the known targeted mutations for this gene in a mouse. |
Art4tm1aWTSI(KOMP) |
| Example structure of targeted conditional mutant allele for this gene |
|
| These Mutant ES Cells can be studied directly or used to generate mice with this gene knocked out. Study of these mice can shed light on the function of Art4: see Knockout mouse |
References
Further reading
- Reid ME (2003). "The Dombrock blood group system: a review". Transfusion 43 (1): 107–14. doi:10.1046/j.1537-2995.2003.00283.x. PMID 12519438.
- Tippett P (1967). "Genetics of the Dombrock blood group system". J. Med. Genet. 4 (1): 7–11. doi:10.1136/jmg.4.1.7. PMC 1468500. PMID 6034522. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1468500.
- Eiberg H, Mohr J (1996). "Dombrock blood group (DO): assignment to chromosome 12p". Hum. Genet. 98 (5): 518–21. doi:10.1007/s004390050251. PMID 8882867.
- Mauthe J, Coghlan G, Zelinski T (2000). "Confirmation of the assignment of the Dombrock blood group locus (DO) to chromosome 12p: narrowing the boundaries to 12p12.3-p13.2". Vox Sang. 79 (1): 53–6. doi:10.1046/j.1423-0410.2000.7910053.x. PMID 10971215.
- Gubin AN, Njoroge JM, Wojda U et al. (2000). "Identification of the dombrock blood group glycoprotein as a polymorphic member of the ADP-ribosyltransferase gene family". Blood 96 (7): 2621–7. PMID 11001920.
- Wu GG, Jin SZ, Deng ZH, Zhao TM (2002). "Polymerase chain reaction with sequence-specific primers-based genotyping of the human Dombrock blood group DO1 and DO2 alleles and the DO gene frequencies in Chinese blood donors". Vox Sang. 81 (1): 49–51. doi:10.1046/j.1423-0410.2001.00052.x. PMID 11520417.
- Rios M, Hue-Roye K, Øyen R et al. (2002). "Insights into the Holley- and Joseph- phenotypes". Transfusion 42 (1): 52–8. doi:10.1046/j.1537-2995.2002.00004.x. PMID 11896313.
- Rios M, Storry JR, Hue-Roye K et al. (2002). "Two new molecular bases for the Dombrock null phenotype". Br. J. Haematol. 117 (3): 765–7. doi:10.1046/j.1365-2141.2002.03524.x. PMID 12028057.
- Glowacki G, Braren R, Firner K et al. (2003). "The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse". Protein Sci. 11 (7): 1657–70. doi:10.1110/ps.0200602. PMC 2373659. PMID 12070318. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2373659.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Grahnert A, Friedrich M, Engeland K, Hauschildt S (2005). "Analysis of mono-ADP-ribosyltransferase 4 gene expression in human monocytes: splicing pattern and potential regulatory elements". Biochim. Biophys. Acta 1730 (3): 173–86. doi:10.1016/j.bbaexp.2005.08.001. PMID 16140404.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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| 1-50 |
CD1 ( a-c, 1A, 1D, 1E) · CD2 · CD3 ( γ, δ, ε) · CD4 · CD5 · CD6 · CD7 · CD8 ( a) · CD9 · CD10 · CD11 ( a, b, c) · CD13 · CD14 · CD15 · CD16 ( A, B) · CD18 · CD19 · CD20 · CD21 · CD22 · CD23 · CD24 · CD25 · CD26 · CD27 · CD28 · CD29 · CD30 · CD31 · CD32 ( A, B) · CD33 · CD34 · CD35 · CD36 · CD37 · CD38 · CD39 · CD40 · CD41 · CD42 ( a, b, c, d) · CD43 · CD44 · CD45 · CD46 · CD47 · CD48 · CD49 ( a, b, c, d, e, f) · CD50
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| 51-100 |
CD51 · CD52 · CD53 · CD54 · CD55 · CD56 · CD57 · CD58 · CD59 · CD61 · CD62 ( E, L, P) · CD63 · CD64 ( A, B, C) · CD66 ( a, b, c, d, e, f) · CD68 · CD69 · CD70 · CD71 · CD72 · CD73 · CD74 · CD78 · CD79 ( a, b) · CD80 · CD81 · CD82 · CD83 · CD84 · CD85 ( a, d, e, h, j, k) · CD86 · CD87 · CD88 · CD89 · CD90 · CD91- CD92 · CD93 · CD94 · CD95 · CD96 · CD97 · CD98 · CD99 · CD100
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| 101-150 |
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| 151-200 |
CD151 · CD152 · CD153 · CD154 · CD155 · CD156 ( a, b, c) · CD157 · CD158 ( a, d, e, i, k) · CD159 ( a, c) · CD160 · CD161 · CD162 · CD163 · CD164 · CD166 · CD167 ( a, b) · CD168 · CD169 · CD170 · CD171 · CD172 ( a, b, g) · CD174 · CD177 · CD178 · CD179 ( a, b) · CD181 · CD182 · CD183 · CD184 · CD185 · CD186 · CD191 · CD192 · CD193 · CD194 · CD195 · CD196 · CD197 · CDw198 · CDw199 · CD200
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| 201-250 |
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| 251-300 |
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| 301-350 |
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